Antibiotics do not work preventively, not even for Lyme disease. The likelihood of contracting Lyme disease after receiving a tick bite is 2-3%. That likelihood will be reduced by half if the tick is removed within a few hours. The best way to do that is by grasping the tick's head with pointed tweezers as close to the skin as possible and gently pulling it out. Do not use alcohol, iodine, oil or other agents before removing the tick. An expanding red skin lesion at the site of the tick bite (erythema migrans) is a manifestation of Lyme disease. If you notice this, consult your doctor immediately and discuss the right treatment.